The prion protein is not required for peripheral nerve de- and remyelination after crush injury

The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peripheral nerves. PrP activates adhesion G-protein coupled receptor Adgrg6 on Schwann cells and initiates a pro-myelination cascade molecular signals. Because crucial for development regeneration after nerve injury, we investigated role repair. We performed experimental sciatic crush injuries co-isogenic wild-type PrP-deficient mice, examined repair processes. Generation cells, macrophage recruitment remyelination were similar mice. conclude that dispensable de- injury. may sustain its function independently activation by PrP.